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	<title>Avail Clinical Research</title>
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		<title>5 Myths Concerning High Cholesterol</title>
		<link>http://www.availclinical.com/news/5-myths-concerning-high-cholesterol/</link>
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		<pubDate>Thu, 10 May 2012 11:37:16 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

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		<description><![CDATA[Do You Have High Cholesterol?
This waxy substance known as “cholesterol” can be found in the lipids (fats) located in the blood stream. The human body needs this cholesterol so that it can continue to form new healthy cells. The problem is that our bodies can produce the cholesterol it&#8230; <a href="http://www.availclinical.com/news/5-myths-concerning-high-cholesterol/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<h2>Do You Have High Cholesterol?</h2>
<p>This waxy substance known as “cholesterol” can be found in the lipids (fats) located in the blood stream. The human body needs this cholesterol so that it can continue to form new healthy cells. The problem is that our bodies can produce the cholesterol it needs to form cells, so we are actually consuming extra cholesterol from the food we eat. Within reason, the extra cholesterol shouldn’t be a problem. Unfortunately, some people may accumulate too much cholesterol, and then it can start to build up in the arteries. The term for this is atherosclerosis, which is a hardening of the arteries. Eventually it can get to the point where there just isn’t enough blood getting pumped through. When the heart isn’t getting the oxygen-rich blood that it needs, this dramatically increases the chance of a heart attack. Also there is an increased risk of a stroke when the brain isn’t getting enough blood either. A smooth supply of blood is an essential piece of the puzzle, and without it, the whole thing can suddenly come apart.</p>
<p>If you would like to participate in a <a href="http://www.availclinical.com/clinical-trials/high-cholesterol/">High Cholesterol Clinical Trial</a>, give us a should and we&#8217;ll see if you qualify for one of our paid trials, like <a href="http://www.availclinical.com/trial/2407">this one here</a>!</p>
<h2>High Cholesterol Myths………..and the Facts!</h2>
<h3>High Rate of Cholesterol in the US</h3>
<p>If you were to look at the rates of obesity in this country, you could assuredly say that we are a country that you could use some slimming down. Recent estimates show that about 35.7% of the adults in this country could be considered obese, that is roughly one-third of the population! On the other hand, we are fairly average when it comes to our cholesterol levels. In a survey taken by the <a href="http://www.who.int/en/" target="_blank">World Health Organization</a>, both American men and women had an average cholesterol level of 197 mg/dL. This number turns out to be just under the borderline high-risk levels. American men ranked 83rd in the world and American women ranked 81st.</p>
<h3>All High Cholesterol Foods are Bad</h3>
<p>Many people can get caught up in avoiding anything that could potentially have cholesterol. The fact is that a number of high cholesterol foods can have a part in a healthy diet. What researchers are finding is that saturated fat is the primary contributor to instances of high cholesterol. In fact, many of the high cholesterol foods that were once considered “bad” don’t contribute to high cholesterol for the majority. Takes eggs for example, which have about 200 mg of dietary cholesterol. This is a significant proportion of what is suggested for the entire day. Fortunately, research has shown that dietary cholesterol is not as bad as it was once thought to be. If eaten in moderation, your body can easily compensate by producing lower levels of cholesterol. Eggs are also contain unsaturated fat and are a good source of protein.</p>
<h3>Peanut Butter and Avocados are both High Cholesterol Food Items</h3>
<p>Looking at a bowl of peanut butter or avocado, it is not surprising that many people assume that these foods are high in cholesterol. While it is true that both of peanut butter and avocados are high in fat, they are both “plant foods”. The only food items that naturally contain cholesterol are products of animals. Just to re-hash, plants don’t produce any cholesterol, while animals produce cholesterol in their bodies. Believe it or not, both peanut butter and avocados can be helpful reducing the risk of high cholesterol! Yes, you read that correctly, they can actually “help prevent” high cholesterol! This because both of them contain a good amount of monounsaturated fat, which has been found to be quite good for you. Avocados are also low in sodium, which is good for our cholesterol levels.</p>
<h3>Kids Aren’t at Risk</h3>
<p>As shocking as it sounds, even kids can be at risk of developing high cholesterol levels in their arteries. Current research has shown that atherosclerosis can start in a child as early as age 8! It is now recommended that children who experience the <a href="http://www.availclinical.com/clinical-trials/high-cholesterol/signs-symptoms/">signs of high cholesterol</a>, are overweight, have hypertension, or have a history of heart disease in their family get there cholesterol levels checked. Children who have high cholesterol need to be put on a diet that restricts the amounts of saturated fat and dietary cholesterol consumed daily.</p>
<h3>With Exercise and Good Diet, There is No Chance of High Cholesterol</h3>
<p>People don’t just develop high cholesterol because of a lack of exercise or a bad overall diet. Research has shown that there are other factors at play here, and these can be quite influential. In all honesty, there are people who have been able to maintain very healthy and fit, but they still need to take cholesterol medication. Well how can this be? If you remember back to earlier, our body produces its own cholesterol in order to form new healthy cells. Well for some people, their body might produce more cholesterol than it can handle. So unfortunately for some, diet and exercise alone may not be enough to maintain healthy cholesterol levels.</p>
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		<title>Welcoming New Phase I Coordinator Ross “Rosco” Meadows</title>
		<link>http://www.availclinical.com/news/welcoming-new-phase-i-coordinator-ross-rosco-meadows/</link>
		<comments>http://www.availclinical.com/news/welcoming-new-phase-i-coordinator-ross-rosco-meadows/#comments</comments>
		<pubDate>Tue, 08 May 2012 18:58:56 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

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		<description><![CDATA[We are pleased to announce the addition of our newest Phase I coordinator, Ross “Rosco” Meadows. Rosco joins us from the Minneola Fire Rescue department, where he has served as Fire Captain since January 2011. He brings many years of both clinical and management experience to our team. Rosco has&#8230; <a href="http://www.availclinical.com/news/welcoming-new-phase-i-coordinator-ross-rosco-meadows/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>We are pleased to announce the addition of our newest Phase I coordinator, Ross “Rosco” Meadows. Rosco joins us from the <a href="http://www.minneola.us/depts/fire.htm" target="_blank">Minneola Fire Rescue department</a>, where he has served as Fire Captain since January 2011. He brings many years of both clinical and management experience to <a href="http://www.availclinical.com/about-us/management-team/" target="_blank">our team</a>. Rosco has over ten years of EMT/Paramedic experience, which also includes a year in Iraq providing emergency pre-hospital care and EMS instructional courses to various US Army units. He holds numerous certifications, including EMT, Paramedic, ACLS, PALS, CPR, and EVOC. He is a certified BLS and ACLS instructor.</p>
<p>Please join me in welcoming Rosco to the Avail team!</p>
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		<title>Sugar Rush! How Sugar Consumption is Changing America [INFOGRAPHIC]</title>
		<link>http://www.availclinical.com/news/sugar-rush-how-sugar-consumption-is-changing-america-infographic/</link>
		<comments>http://www.availclinical.com/news/sugar-rush-how-sugar-consumption-is-changing-america-infographic/#comments</comments>
		<pubDate>Wed, 02 May 2012 18:46:51 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.availclinical.com/?p=2342</guid>
		<description><![CDATA[The fact of the matter is that Americans are eating too much sugar as a whole. For many people in the US, their diet has been getting steadily worse over the years. The average diet for an American has become too high in calories, and it does not contain enough&#8230; <a href="http://www.availclinical.com/news/sugar-rush-how-sugar-consumption-is-changing-america-infographic/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>The fact of the matter is that Americans are eating too much sugar as a whole. For many people in the US, their diet has been getting steadily worse over the years. The average diet for an American has become too high in calories, and it does not contain enough of the nutrients and other essentials that we need to stay healthy. These diet trends have been having a disastrous effect on our population. In 2007, it was estimated that 57 million Americans had pre-diabetes. As of 2011, the estimated number of people with pre-diabetes has grown to 79 million! At this stage, the body’s blood glucose levels are higher than the healthy level, and you are at serious risk of developing type 2 diabetes and heart disease.</p>
<p style="text-align: center;"><a href="http://www.availclinical.com/wp-content/uploads/2012/05/design-e1335986769675.jpg" target="_blank"><img class="wp-image-2344 aligncenter" title="Sugar Consumption Infographic" src="http://www.availclinical.com/wp-content/uploads/2012/05/design.jpg" alt="Sugar Consumption Infographic | How Sugar is Changing America" width="610" height="1480" /></a></p>
<p>It is a myth that eating too much sugar is a direct cause of diabetes. While sugar may not be a direct cause, a diet that is high in sugar can lead to obesity, which in turn can lead to increased risk of diabetes. The rate of obesity in the country has been steadily rising over the last several years, and it continues to go up. The number of cases of <a href="http://www.availclinical.com/clinical-trials/diabetes/type-2-diabetes/">type 2 diabetes</a> in the US has been climbing in positive correlation with the rate of obesity. Type 2 diabetes is the most common form, accounting for about 90% of all cases. A majority of type 2 diabetes patients are also overweight. A person who is at an unmanageable weight is putting themselves in a lot of risk. This excess weight can make it harder for the body to produce and use insulin effectively.</p>
<h2>Obesity and Diabetes Stats in the United States</h2>
<p>The current estimates are that there are 25.8 million people in the United States who are affected by diabetes. That is 8.3% of the entire US population who have diabetes. Only 18.8 million have actually been diagnosed, which means that there are 7 million people who are undiagnosed. These numbers are quite shocking, and as the rate of obesity keeps going up, the number of T2D cases is expected to continue to increase. Also, be sure to check out some of the <a href="http://www.availclinical.com/news/diabetes-organizations-worth-learning-about/">diabetes organizations worth knowing about</a>!</p>
<p>Back in 1915, the average American consumed roughly between 15 – 20 pounds of sugar annually. Now the USDA estimates that the average amount of sugar consumed in a year is 156 pounds! Looking at these numbers, one may not be as shocked to learn that roughly one third (35.7 %!!) of the American population is considered obese. The rate of obesity has skyrocketed among children and adolescents as well with an estimated 17% or 12.5 million now considered obese.</p>
<p>Diabetes is currently the seventh leading cause of death in the United States. In 2007, diabetes was listed as the underlying cause of death on 71,382 death certificates. That year, diabetes was listed as a contributing factor on 160,022 death certificates. So in the year 2007, diabetes was in some way involved in the deaths of 231,404 deaths! With diabetes, your overall risk of death is about doubled compared to other people in the same age range. This may also be the reason for the increasing number of <a href="http://www.availclinical.com/clinical-trials/diabetes/">diabetes clinical trials</a>.</p>
<h2>The Sugar Content in Some Foods May Shock You!</h2>
<p>Taking a trip to your local grocer, you may be very surprised at what you see if you took a look at the nutritional information for some foods. Many items, which a lot of people assume are generally healthy, can contain a lot more sugar than you’d expect. The info-graphic, How Sugar Has Been Changing America, lists more than 10 food items which are surprisingly high in sugar. For example, it probably won’t come as much of a shock to learn that a can of Mountain Dew contains 46.5 grams of sugar. If you have ever tried one, you’d know that it is one surgery beverage! So how about a drink like Sobe Energize Green Tea? That sounds like a drink that should be relatively good for you right?? In fact, a 20 ounce bottle of Sobe Energize Green Tea packs a whopping 61 grams of sugar! That is about the same as adding 15 sugar cubes to your tea! Pardon me, but would you like some tea with that sugar?? Be sure to check out the info-graphic as it lists a number of other surprising food items that pack a surgery punch.</p>
<h2>Sugar Substitutes – How Safe Are They?</h2>
<h3><strong>Product name: </strong>Sweet N Low</h3>
<p><strong>Key Ingredient:</strong> Saccharin</p>
<p><strong>Negative Characteristics:</strong> According to FDA reports, the key ingredient saccharin had been linked to cases of bladder cancer in lab tested animals; this was what prompted the health warning label on sweet n low packages back in 1977. The label was removed back in 2001, and there have been studies suggesting that it doesn’t cause cancer in humans, but the dangers of saccharin remain controversial. While saccharin has been currently “delisted” as a carcinogen in humans, there is still increased risk in some small sub-groups like heavy users of these artificial sweeteners.</p>
<h3><strong>Product name: </strong>Equal</h3>
<p><strong>Key Ingredient:</strong> Aspartame</p>
<p><strong>Negative Characteristics:</strong> There are reports that Aspartame which is used in artificial sweeteners like Equal could be toxic. It has been investigated as a possible cause of mental retardation, brain tumors, epilepsy, Parkinson’s disease, birth defects, diabetes, and fibromyalgia. Since it was first approved by the FDA, Aspartame has stirred up a lot of controversy.</p>
<h3><strong>Product name: </strong>Splenda</h3>
<p><strong>Key ingredient:</strong> Sucralose</p>
<p><strong>Negative Characteristics:</strong> The debate continues over how thoroughly sucralose was tested by the FDA. Basically the long term effects of splenda are still unknown. Some tests have shown atrophy of lymph follicles in the thymus and spleen, signs of shrunken thymus glands, increased cercal weight, and lowered red blood cell count among other things. In diabetics, Splenda can cause an increase in glycosylated hemoglobin, which could harm that person’s control over their condition. There is chlorine in sucralose, which means consuming a large quantity could be toxic.</p>
<h3><strong>Product name: </strong>Truvia</h3>
<p><strong>Key Ingredient:</strong> Stevia</p>
<p><strong>Negative Characteristics:</strong> Truvia is still a relatively new product, but so far it has been linked with some gastrointestinal issues such as causing gas, bloating, and constipation in users. These effects have been reported with consumption of large amounts of truvia. Some other possible side effects could be headaches and exhaustion. Since Stevia is an herb, some people may experience an allergic reaction from consuming Truvia.</p>
<h3><strong><strong>Product name: </strong>Brown Sugar</strong></h3>
<p>Brown raw sugar is a natural sweetener developed from sugar crystals of molasses syrup. This is a good substitute for regular white sugar for a few reasons. First, brown sugar contains fewer calories than white sugar. Since this is the unrefined form of sugar, it retains a higher nutritional value. There are also other natural components contained in the brown sugar that make it beneficial to human health.</p>
<p>&nbsp;</p>
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		<title>Diabetes Organizations worth Learning About</title>
		<link>http://www.availclinical.com/news/diabetes-organizations-worth-learning-about/</link>
		<comments>http://www.availclinical.com/news/diabetes-organizations-worth-learning-about/#comments</comments>
		<pubDate>Tue, 24 Apr 2012 17:14:41 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

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		<description><![CDATA[Diabetes has become a very important topic in the United States in recent years, including the increasing number of diabetes clinical trials. With the number of cases for both type 1 and type 2 estimated to keep going up, these diseases are affecting more people than ever before. Unfortunately many&#8230; <a href="http://www.availclinical.com/news/diabetes-organizations-worth-learning-about/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>Diabetes has become a very important topic in the United States in recent years, including the increasing number of <a href="http://www.availclinical.com/clinical-trials/diabetes/">diabetes clinical trials</a>. With the number of cases for both type 1 and type 2 estimated to keep going up, these diseases are affecting more people than ever before. Unfortunately many Americans are still unaware of the differences between <a href="http://www.availclinical.com/clinical-trials/diabetes/type-1-diabetes/">type 1 diabetes</a> and <a href="http://www.availclinical.com/clinical-trials/diabetes/type-2-diabetes/">type 2 diabetes</a>, but there are established organizations and other groups which have been working hard to help spread awareness of these diseases. They know that better education and more knowledge can help to save precious lives, and this is a movement that is getting a lot of backing.</p>
<h2>The History of Diabetes</h2>
<p>Human beings have known of this affliction for thousands of years. Descriptions have been found in Egyptian papyrus that mentioned a rare disease which caused frequent urination and rapid weight loss. A Greek physician named Aretaeus coined the term diabetes which also meant “flow”, due to the frequent urination caused by the affliction. Mellitus which means “honey” was then added implying the existence of sugar in the urine. Over the years, diabetes mellitus symptoms were described as an abnormal appetite, the urine had a sweet taste, and a collapse of sexual functions. In these ancient times, early physicians could recognize the symptoms of diabetes mellitus, but they had no method of effectively treating it.</p>
<h2>Prominent Diabetes Organizations</h2>
<p><strong>American Diabetes Association (ADA):</strong> As the name clearly states, this is organization is based in the United States. Established back in 1940 by physicians, ADA is now a volunteer driven organization. The <a href="American Diabetes Association">American Diabetes Association</a> has become the leading non-profit charity in the U.S. working to combat the complications of diabetes mellitus. ADA provides significant funding for diabetes clinical research. This research has been instrumental in developing better ways to manage and help prevent all forms of diabetes including type 1 and type 2 diabetes, gestational diabetes, and pre-diabetes. ADA has been responsible for providing effective services to hundreds of communities, and they have a well established website which provides the most up-to-date information for patients and health care professionals.</p>
<p><strong>Juvenile Diabetes Research Foundation (JDRF):</strong> This is the leading worldwide organization dedicated to type 1 diabetes research. <a href="http://www.jdrf.org/">JDRF</a> is driven by volunteers who feel a deep connection to the children, adolescents, and adults who have this disease. This organization’s success has made them the largest charitable supporter for type 1 diabetes research in the world. JDRF’s mission is to accelerate the progress made with the most promising treatments, methods of prevention, and opportunities for a cure, so that they may improve the quality of life for every person who has T1D. This foundation was established in 1970, and since then has been able to give over $1 billion towards type 1 diabetes research.</p>
<p><strong>International Diabetes Federation (IDF):</strong> This is another global diabetes organization which is made up of some 200 diabetes associations which encompass more than 150 countries. <a href="http://www.idf.org/">IDF</a> has made it their mission to help better the lives of people with diabetes all over the world. To achieve this monumental goal, IDF is devoted to raising awareness for diabetes, establishing better treatment and prevention methods, and backing increased efforts to discover a cure for every type of diabetes. The success of this federation has depended on a collaborative effort from the top stakeholders in the diabetes community to establish goals and then work cooperatively to accomplish them.</p>
<p><strong>Diabetes Exercise and Sports Association (DESA):</strong> For a long time, it was believed that exercise could cause a diabetics blood sugar to decrease, so doctors would recommend that people with diabetes should refrain from too much physical activity. Today, physicians have realized that regular physical activity and exercise can help diabetics manage their symptoms. The DESA was established in order to help improve the quality of life for people with diabetes through exercise and physical fitness. This association was started in 1985 by Paula Harper. Paula was a registered nurse with diabetes, who also participated in marathons and knew other athletes with diabetes. Her organization has helped to shed light on how exercise can affect diabetes and also spread awareness of its benefits for people with diabetes. <a href="http://www.desa.org.nz/">DESA</a> works closely with healthcare professionals to help improve the physical skills of people with type 1 and type 2 diabetes.</p>
<p><strong>Diabetes Education and Camping Association (DECA):</strong> This organization was established in 1997, and it serves as the worldwide voice for diabetes camps and camping. <a href="http://www.diabetescamps.org/">DECA</a> works to assist diabetes camp organizations all around the world by establish networking and resources in order to improve and expand their programs. They have also been very effective at establishing improved guidelines for diabetes education and management at these camps. DECA creates programs that help to inspire real confidence in the children, adolescents and families which are affected by this disease.</p>
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		<title>The Signs &amp; Symptoms of Diabetes</title>
		<link>http://www.availclinical.com/news/signs-symptoms-of-diabetes/</link>
		<comments>http://www.availclinical.com/news/signs-symptoms-of-diabetes/#comments</comments>
		<pubDate>Fri, 20 Apr 2012 17:57:51 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

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		<description><![CDATA[Glucose is an important form of sugar needed by the cells of the human body. The body gets its needed glucose from the glucose made in the liver and muscles as well as from the foods we eat. In order for glucose to be absorbed by the cells, insulin, a&#8230; <a href="http://www.availclinical.com/news/signs-symptoms-of-diabetes/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>Glucose is an important form of sugar needed by the cells of the human body. The body gets its needed glucose from the glucose made in the liver and muscles as well as from the foods we eat. In order for glucose to be absorbed by the cells, insulin, a chemical made in the pancreas, is needed. If an insufficient amount of insulin is produced, or if the insulin is not functioning suitably, the glucose won’t be taken as needed by the cells, and it will build up in the blood stream. This build-up causes high blood sugar, which leads to diabetes.</p>
<p>(<strong>see also</strong>: <a href="http://www.availclinical.com/clinical-trials/diabetes/">Diabetes Clinical Studies</a>)</p>
<p>Pre-diabetes, <a href="http://www.availclinical.com/clinical-trials/diabetes/type-1-diabetes/">type I diabetes</a>, type II diabetes, gestational diabetes, congenital diabetes, cystic fibrosis-related diabetes, steroid diabetes and monogenic diabetes are the eight types of diabetes. Each type of diabetes is a result of glucose build-up in the body. This can happen to people of all ages and with all sorts of dietary habits.</p>
<p>Pre-diabetes results when the blood glucose levels are higher than they should be, but not high enough to qualify for a diabetes diagnosis. Patients with pre-diabetes have a higher risk of heart disease and stroke. People with pre-diabetes also have a greater <a href="http://www.availclinical.com/clinical-trials/diabetes/type-2-diabetes/">chance of developing Type II diabetes</a>.</p>
<p>When the immune system attacks and destroys the beta cells of the pancreas, the beta cells stop producing insulin. This leads to Type I diabetes. Type I diabetes (formerly known as juvenile diabetes or insulin-dependent diabetes) is usually diagnosed in children, teenagers and young adults.</p>
<p>Upon insulin resistance, a disorder in which fat, muscle and liver cells are not properly using insulin, Type II diabetes (formerly known as adult-onset diabetes or noninsulin-dependent diabetes) results. The pancreas is forced to produce enough insulin to keep up with the increased insulin demand. However, over time the pancreas becomes incapable of secreting enough insulin after a person has eaten a meal and fills the blood stream with glucose. Lack of physical activity and being overweight increases a person’s risk of developing this type of diabetes.</p>
<p>Gestational diabetes is a form of diabetes in the late stages of pregnancy caused by hormonal changes and/or a shortage of insulin. After the baby is born, gestational diabetes usually goes away and blood glucose levels return to normal. Women diagnosed with gestational diabetes are at higher risk of developing Type II diabetes in later years.</p>
<p>Some people do not experience any symptoms before their <a href="http://www.availclinical.com/clinical-trials/diabetes/type-1-diabetes/type-1-diabetes-tests-and-diagnosis/">diabetes diagnoses</a>. Symptoms may become present rapidly (in a matter of weeks or months), typical for type I diabetes, or much more slowly, as is typical for type II. The following are <a href="http://www.availclinical.com/clinical-trials/diabetes/type-1-diabetes/signs-symptoms/">symptoms of diabetes</a>: polydipsia (severe thirst), polyuria (frequent urination), polyphagia (severe hunger), diabetic dermadromes (rashes), exhaustion, unintentional weight loss, dry or itchy skin, slowly healing sores, tingling of the feet , numbness in the feet, blurred vision, ischemic heart disease, peripheral vascular disease, stroke, damage to blood vessels, diabetic retinopathy (a result of damage to blood vessels), diabetic neuropathy (a result of damage to blood vessels), diabetic nephropathy (a result of damage to blood vessels) and diabetic foot ulcers (a result of damage to blood vessels).</p>
<p>If not treated adequately, <a href="http://www.mayoclinic.com/health/diabetes/DS01121">diabetes</a> can worsen and more symptoms may arise. Therefore, it is crucial that diabetes be properly medically treated. There are numerous severe signs of diabetes that result from lack of treatment, including: nonketotic hyperosmolar coma, dehydration (a symptom/result of nonketotic hyperosmolar coma), hyperglycemia, retinal damage, cardiovascular disease, chronic renal failure and diabetic ketoacidosis.</p>
<p>Sticking to a healthy diet, keeping cholesterol and blood pressure in check and engaging in physical activity are ways that all people can help prevent or treat diabetes. There is no vaccine or pill that cures diabetes, but there are many clinical trials underway to discover one. Diabetes is a life-altering disease, but it can be managed. Speak to your health care provider to discuss the best approach to manage your case.</p>
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		<title>Understanding Diabetes &#8211; Signs and Symptoms</title>
		<link>http://www.availclinical.com/news/understanding-diabetes-signs-and-symptoms/</link>
		<comments>http://www.availclinical.com/news/understanding-diabetes-signs-and-symptoms/#comments</comments>
		<pubDate>Wed, 11 Apr 2012 01:54:12 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

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		<description><![CDATA[Glucose is an important form of sugar needed by the cells of the human body. The body gets its needed glucose from the glucose made in the liver and muscles as well as from the foods we eat. In order for glucose to be absorbed by the cells, insulin, a&#8230; <a href="http://www.availclinical.com/news/understanding-diabetes-signs-and-symptoms/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>Glucose is an important form of sugar needed by the cells of the human body. The body gets its needed glucose from the glucose made in the liver and muscles as well as from the foods we eat. In order for glucose to be absorbed by the cells, insulin, a chemical made in the pancreas, is needed. If an insufficient amount of insulin is produced, or if the insulin is not functioning suitably, the glucose won’t be taken as needed by the cells, and it will build up in the blood stream. This build-up causes high blood sugar, which leads to diabetes.</p>
<p>Pre-diabetes, <a href="http://www.availclinical.com/clinical-trials/diabetes/type-1-diabetes/">type I diabetes</a>, <a href="http://www.availclinical.com/clinical-trials/diabetes/type-2-diabetes/">type II diabetes</a>, gestational diabetes, congenital diabetes, cystic fibrosis-related diabetes, steroid diabetes and monogenic diabetes are the eight types of <a href="http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002194/">diabetes</a>. Each type of diabetes is a result of glucose build-up in the body. This can happen to people of all ages and with all sorts of dietary habits.</p>
<p>Pre-diabetes results when the blood glucose levels are higher than they should be, but not high enough to qualify for a diabetes diagnosis. Patients with pre-diabetes have a higher risk of heart disease and stroke. People with pre-diabetes also have a greater chance of developing Type II diabetes.</p>
<p>When the immune system attacks and destroys the beta cells of the pancreas, the beta cells stop producing insulin. This leads to Type I diabetes. Type I diabetes (formerly known as juvenile diabetes or insulin-dependent diabetes) is usually diagnosed in children, teenagers and young adults.</p>
<p>Upon insulin resistance, a disorder in which fat, muscle and liver cells are not properly using insulin, Type II diabetes (formerly known as adult-onset diabetes or noninsulin-dependent diabetes) results. The pancreas is forced to produce enough insulin to keep up with the increased insulin demand. However, over time the pancreas becomes incapable of secreting enough insulin after a person has eaten a meal and fills the blood stream with glucose. Lack of physical activity and being overweight increases a person’s risk of developing this type of diabetes.</p>
<p>Gestational diabetes is a form of diabetes in the late stages of pregnancy caused by hormonal changes and/or a shortage of insulin. After the baby is born, gestational diabetes usually goes away and blood glucose levels return to normal. Women diagnosed with gestational diabetes are at higher risk of developing Type II diabetes in later years.</p>
<p>Some people do not experience any symptoms before their diabetes diagnoses. Symptoms may become present rapidly (in a matter of weeks or months), typical for type I diabetes, or much more slowly, as is typical for type II.</p>
<p>The following are symptoms of diabetes: polydipsia (severe thirst), polyuria (frequent urination), polyphagia (severe hunger), diabetic dermadromes (rashes), exhaustion, unintentional weight loss, dry or itchy skin, slowly healing sores, tingling of the feet , numbness in the feet, blurred vision, ischemic heart disease, peripheral vascular disease, stroke, damage to blood vessels, diabetic retinopathy (a result of damage to blood vessels), diabetic neuropathy (a result of damage to blood vessels), diabetic nephropathy (a result of damage to blood vessels) and diabetic foot ulcers (a result of damage to blood vessels).</p>
<p>If not treated adequately, diabetes can worsen and more symptoms may arise. Therefore, it is crucial that diabetes be properly medically treated. There are numerous severe signs of diabetes that result from lack of treatment, including: nonketotic hyperosmolar coma, dehydration (a symptom/result of nonketotic hyperosmolar coma), hyperglycemia, retinal damage, cardiovascular disease, chronic renal failure and diabetic ketoacidosis.</p>
<p>Sticking to a healthy diet, keeping cholesterol and blood pressure in check and engaging in physical activity are ways that all people can help prevent or treat diabetes. There is no vaccine or pill that cures diabetes, but there are many clinical trials underway to discover one. Diabetes is a life-altering disease, but it can be managed. Speak to your health care provider to discuss the best approach to manage your case.</p>
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		<title>Signs and Symptoms of Hepatitis C</title>
		<link>http://www.availclinical.com/news/signs-and-symptoms-of-hepatitis-c/</link>
		<comments>http://www.availclinical.com/news/signs-and-symptoms-of-hepatitis-c/#comments</comments>
		<pubDate>Tue, 27 Mar 2012 03:15:20 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.availclinical.com/?p=2276</guid>
		<description><![CDATA[The infectious disease hepatitis C is caused by the hepatitis C virus (HCV). The disease, known vernacularly as “hep C”, primarily affects the liver and can cause cirrhosis (severe scarring) in chronic cases. A large percentage of acute hep C cases are asymptomatic, and 10-50% of these acute infections cure&#8230; <a href="http://www.availclinical.com/news/signs-and-symptoms-of-hepatitis-c/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>The infectious disease <a href="http://www.availclinical.com/clinical-trials/hepatitis-c/hepatitis-c-diagnosis-tests/">hepatitis C</a> is caused by the hepatitis C virus (HCV). The disease, known vernacularly as “hep C”, primarily affects the liver and can cause cirrhosis (severe scarring) in chronic cases. A large percentage of acute hep C cases are asymptomatic, and 10-50% of these acute infections cure themselves.</p>
<p>85% of acute HCV infections are asymptomatic, and the 15% of symptomatic cases generally involve mild symptoms. <a href="http://www.availclinical.com/clinical-trials/hepatitis-c/hepatits-c-signs-symptoms/">Signs of acute HCV</a> include:</p>
<ul>
<li>decreased appetite</li>
<li>nausea</li>
<li>muscle or joint pain</li>
<li>weight loss</li>
<li>fatigue</li>
<li>jaundice, the yellow-hued pigmentation of the skin, sclerae (whites of the eyes) and other mucous membranes</li>
</ul>
<p>About 80% of hep C patients develop a chronic HCV infection. Asymptomatic and acute cases could last for decades before becoming chronic. Chronic HCV cases may require liver transplants. Hep C is the leading cause for liver transplants. The disease tends to recur post transplants, however.</p>
<p>Most patients with chronic hep C experience few or no symptoms of the infection for the first few decades. Over a 30-year period about 20% of those with chronic HCV develop liver cirrhosis and may require liver transplants. After decades with hep C, the infection becomes the chief cause of cirrhosis.</p>
<p>Cirrhosis is a condition in which liver tissue is replaced by scar tissue, nodules and fibrosis. Hep C causes 27% of liver cirrhosis cases across the globe. Cirrhosis eventually leads to liver failure. Severe cases may require liver transplants.</p>
<p>Liver cirrhosis can lead to the following:</p>
<ul>
<li>varices (lethally enlarged veins commonly in the stomach and esophagus)</li>
<li>jaundice, bruising and bleeding</li>
<li>ascites (build-up of fluid in the abdomen)</li>
<li>hypertension in the portal vein</li>
<li>hepatic encephalopathy (the cognitive impairment, confusion, coma and altered level of consciousness caused by the accumulation of toxins in the blood that the failing HCV-infected liver no longer removes)</li>
</ul>
<p>Hep C is seldom associated with the following disorders:</p>
<ul>
<li>Sjogren’s syndrome</li>
<li>lichen planus</li>
<li>diabetes</li>
<li>thrombocytopeniamixed cryoglobulinemia</li>
<li>B-cell lymphoproliferative disorders</li>
<li>Hyde’s prurigo nodularis</li>
<li>membranoproliferative glomerulonephritis</li>
</ul>
<p>Although there is no cure for hep C, there are <a href="http://www.availclinical.com/clinical-trials/hepatitis-c/">many clinical studies</a> taking place worldwide to discover a cure and therapies for those infected with HCV. There is no currently available vaccine against the HCV. However, there are available medications and surgeries to improve patients’ quality of life. Talk to your doctor to find out what is best for you.</p>
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		<title>New Diabetes Drug Galvus Aims to Combat Increasing Number of Diabetics</title>
		<link>http://www.availclinical.com/news/new-diabetes-drug-galvus-aims-to-combat-increasing-number-of-diabetics/</link>
		<comments>http://www.availclinical.com/news/new-diabetes-drug-galvus-aims-to-combat-increasing-number-of-diabetics/#comments</comments>
		<pubDate>Sat, 17 Mar 2012 16:59:00 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.availclinical.com/?p=2258</guid>
		<description><![CDATA[In the year 1995, there were about 135 million people around the globe with diabetes mellitus. In 2010, that number rose to 285 million, and in 2011 there were an estimated 366 million. Statistics indicate that by 2030 there will be a whopping 552 million people worldwide with diabetes, 80%&#8230; <a href="http://www.availclinical.com/news/new-diabetes-drug-galvus-aims-to-combat-increasing-number-of-diabetics/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>In the year 1995, there were about 135 million people around the globe with <a href="http://www.availclinical.com/clinical-trials/diabetes/">diabetes mellitus</a>. In 2010, that number rose to 285 million, and in 2011 there were an estimated 366 million. Statistics indicate that by 2030 there will be a whopping 552 million people worldwide with diabetes, 80% of whom will be from middle income and poor countries such as Kenya, Botswana and Ghana. In 2011, 4.6 million people died from diabetes. An even scarier fact is that about 50% of patients currently living with diabetes are undiagnosed. The new diabetes drug, Galvus, may be the marvel that lowers these striking numbers.</p>
<p>(see also: <a href="http://www.availclinical.com/trial/2381">Diabetes Clinical Trials</a>)</p>
<p>The dramatic rise of diabetic populations can be attributed to progressively more unhealthy lifestyles, lack of exercise, unhealthy eating habits and an increasing aging population. The therapies available for diabetes do not take care of these problems. Novartis Ghana set out to discover a drug that could.</p>
<p>Glucose is an important form of sugar needed by the cells of the human body. The human body needs glucose, an important form of sugar, for vital metabolic activities. The body gets its needed doses from the glucose made in the liver and muscles as well as from the foods we eat. In order for glucose to be absorbed by the cells, insulin, a chemical made in the pancreas, is needed. If an insufficient amount of insulin is produced, or if the insulin is not functioning suitably, the glucose won’t be taken as needed by the cells, and it will build up in the blood stream. This build-up causes high blood sugar, which leads to pre-diabetes or <a href="http://www.availclinical.com/news/comparing-type-i-diabetes-vs-type-ii-diabetes/">Type I or Type II diabetes</a>.</p>
<p>When the immune system attacks and destroys the beta cells of the pancreas, the beta cells stop producing insulin. This leads to Type I diabetes. Type I diabetes (formerly known as juvenile diabetes or insulin-dependent diabetes) is usually diagnosed in children, teenagers and young adults.</p>
<p>Upon insulin resistance, a disorder in which fat, muscle and liver cells are not properly using insulin, Type II diabetes (formerly known as adult-onset diabetes or noninsulin-dependent diabetes) results. The pancreas is forced to produce enough insulin to keep up with the increased insulin demand. However, over time the pancreas becomes incapable of secreting enough insulin after a person has eaten a meal and fills the blood stream with glucose. Lack of physical activity and being overweight increases a person’s risk of developing this type of diabetes.</p>
<p>Galvus, the new drug developed by Novartis Ghana, can be taken with or without Metformin for progression in the treatment of type II diabetes and hypertension. Roland Hammond, manager of Novartis Ghana, says that expected side effects of the new drug include nausea, diarrhea and vomiting. Galvus will not cause weight gain and hypoglycinium as do other diabetes therapies. Galvus won’t do its job alone; patients still need to live healthy lifestyles involving physical activity, healthy diets, controlling diabetes with medications and keeping blood pressure and cholesterol in check. Since insulin became available in 1921, both diabetes I and II have been able to be controlled with drugs. With the new Galvus, hopefully diabetes will not only be controlled but diabetes populations will decrease.</p>
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		<title>New Hep C Drug Victrelis Awaiting Final Approval</title>
		<link>http://www.availclinical.com/news/hep-c-drug-victrelis/</link>
		<comments>http://www.availclinical.com/news/hep-c-drug-victrelis/#comments</comments>
		<pubDate>Sat, 03 Mar 2012 17:26:07 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.availclinical.com/?p=2243</guid>
		<description><![CDATA[Victrelis is the start of a new era. Millions of hepatitis C positive patients around the world will benefit from this drug once its final draft guidance is confirmed and England’s National Institute for Health and Clinical Excellence (NICE) approves the drug for use. Victrelis is a new drug developed&#8230; <a href="http://www.availclinical.com/news/hep-c-drug-victrelis/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p><strong>Victrelis</strong> is the start of a new era. Millions of hepatitis C positive patients around the world will benefit from this drug once its final draft guidance is confirmed and England’s National Institute for Health and Clinical Excellence (NICE) approves the drug for use. Victrelis is a new drug developed to combat hepatitis C in a way that no other currently available drug or therapy can. It is the first major advancement in the <a href="http://www.availclinical.com/trial/2522" target="_blank">treatment of hepatitis C</a> in over a decade.</p>
<h3><strong>See also:</strong> <a href="http://www.availclinical.com/clinical-trials/hepatitis-c/" target="_blank">Hepatitis C Clinical Trials</a></h3>
<p>Boceprevir, marketed as Victrelis by America’s Merck &amp; Co., can treat the most common subtype of chronic hepatitis C (genotype 1) for patients with liver disease. Most patients diagnosed with genotype 1 are treated with the drugs peginterferon alfa and ribavirin. About 40% of these patients are cured. Using boceprevir in addition to these aforementioned medications increases the treatment rate to 70%. Peginterferon alfa and ribavirin enhance the strength of the immune system and Victrelis narrows in on the virus and prevents the virus from further replication.</p>
<p>The infectious disease hepatitis C is caused by the hepatitis C virus (HCV). The disease, known vernacularly as “hep C”, primarily affects the liver and can cause severe scarring in chronic cases. The severe scarring may lead to cirrhosis and either liver failure, deathly esophageal and gastric varices (lethal enlarged veins) or liver cancer. A large percentage of hep C cases are asymptomatic, and 10-50% of these acute infections cure themselves.</p>
<p>Meindert Boysen, program director technology appraisals at <a href="http://www.nice.org.uk/" target="_blank">NICE</a>, said: “The significant improvement in sustained virological response rates seen with boceprevir plus peginterferon alfa and ribavirin compared with peginterferon alfa and ribavirin alone represents a major benefit for people with genotype 1 chronic hepatitis C. In the past, patients have declined treatment because the perceived chance of a sustained virological response with peginterferon alfa plus ribavirin was too low for them to accept the associated side effects. We…recommend boceprevir as a cost-effective use of NHS [National Health Service] resources.” Although the drug is very costly (about $48,400 for a 44-week period of pills), it has proven to be a cost-effective option since it has proven to be so successful in its treatment of genotype 1 chronic hepatitis C.</p>
<p>There are about 150 million people across the globe currently infected with HCV. About 85% of these cases are based in the liver, and 50-80% of these cases that receive treatment will be cured. About 9,000 deaths occur due to HCV in the United States each year. It is to be expected that more chronic cases will arise in the next number of years and the mortality rate due to hep C will rise, as these cases will be involving those patients who had contracted the disease before HCV testing became available. Hopefully, with the help of Victrelis, the death rate will go down rather than up.</p>
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		<title>Clinical Trials in Orlando, FL – Avail Clinical Research Overview</title>
		<link>http://www.availclinical.com/news/clinical-trials-in-orlando-fl-avail-clinical-research-overview/</link>
		<comments>http://www.availclinical.com/news/clinical-trials-in-orlando-fl-avail-clinical-research-overview/#comments</comments>
		<pubDate>Fri, 06 Jan 2012 17:08:29 +0000</pubDate>
		<dc:creator>ben</dc:creator>
				<category><![CDATA[News]]></category>

		<guid isPermaLink="false">http://www.availclinical.com/?p=1736</guid>
		<description><![CDATA[Clinical research being done today has helped to develop new medications which have vastly improved the quality of life for many people. Participating in a clinical study can be a great option and not just for people who have a disease or condition. There are a broad range of clinical&#8230; <a href="http://www.availclinical.com/news/clinical-trials-in-orlando-fl-avail-clinical-research-overview/" class="read_more">Read More</a>]]></description>
			<content:encoded><![CDATA[<p>Clinical research being done today has helped to develop new medications which have vastly improved the quality of life for many people. <a href="http://www.availclinical.com/clinical-study">Participating in a clinical study</a> can be a great option and not just for people who have a disease or condition. There are a broad range of clinical trials being conducted near Orlando at Avail Clinical Research facility.</p>
<p>Have you been diagnosed with diabetes? If yes, then participating in a <a href="http://www.availclinical.com/trial/areas-served/orlando-fl/">clinical trial in Orlando</a> can provide you with access to state of the art treatment and physician care. The range of different conditions that Avail Clinical Research focuses on is incredible. There are clinical trials enrolling for Crohn’s disease, fibromyalgia, hepatitis B and C, constipation, COPD, osteoporosis, and overactive bladder just to name a few. Their <a href="http://www.availclinical.com/our-medical-staff">highly qualified staff has expertise in a very diverse range of medical fields</a>, so they can certainly handle a lot.</p>
<p>The Avail staff includes a team of clinical research coordinators assigned to every trial. Their physicians are all board certified and they act as the primary investigators with oversight on all trials. Avail employs a laboratory staff, an entire recruiting call center on site, receptionist, and pharmacist. Avail Clinical Research’s goal is to conduct thorough <a href="http://www.availclinical.com/clinical-study/types-of-trials/phase-i-trials/">phase I clinical trials in the Orlando area</a>. To do this they need dedicated phase I staff, they are very well trained and committed to bringing people the best medical care possible.</p>
<p>Avail Clinical Research is primarily focused on conducting phase I clinical research trials. <a href="http://www.achieveclinical.com/">Their sister site in Birmingham, AL focuses on phase II-IV clinical trials</a>, and this cooperative system works out really well benefiting both sites. Their research facility is state of the art and fully equipped to handle the wide array of clinical research trials that are being conducted here. They have the latest medical equipment on hand, and their staff is fully trained in utilizing these tools effectively. If that isn’t impressive enough, the facilities location could not be better. Located within DeLand’s medical community, two other major medical facilities are a stones throw away from Avail Clinical Research.</p>
<p>One of the most important aspects of running a successful clinical research facility is having the ability to effectively recruit the necessary numbers of people for your clinical research studies. Fortunately, Avail Clinical Research maintains an on-site recruiting call center team, which is fully capable of enrolling clinical trial volunteers on a continual basis. Potential volunteers include not only special patient populations but also healthy volunteers. Avail keeps an up to date database of over 50,000 prospective and past patients. With its dedicated and well-trained staff, <a href="http://www.availclinical.com/">Avail Clinical Research</a> will always be able to meet its recruitment goals and help further modern medicine.</p>
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