Chronic Kidney Disease & Renal Impairment

Diagram depicting renal impairment's effect on kidneysDo you know why we are conducting clinical trials for renal impairment & chronic kidney failure? The symptoms of acute kidney injury will get steadily more pronounced over time unless action is taken to address the underlying issues. Conducting clinical trials give us an opportunity to test promising new therapies for chronic kidney disease (CKD), as well as gaining more insight into how these diseases work. They can also provide a life-changing opportunity for people who’ve exhausted more conventional renal impairment treatments.

The kidneys are responsible for filtering out excess fluids and waste from the bloodstream. This filtered byproducts are what eventually is excreted from the body as urine. If someone develops a renal impairment, it means that their kidneys aren’t able to complete this essential task. When the kidneys can’t filter the blood, waste, excess fluids and electrolytes can build up in the body. It’s a serious problem that can become deadly.

Fast Facts About Renal Impairment

  • 1 in 3 American adults is at risk for developing kidney disease
  • 1 in 9 American adults has kidney disease and the majority don’t know it
  • The leading causes of renal impairment are diabetes and hypertension
  • Human beings are born with two kidneys, but only need one to survive

(You can find more information about these medical conditions on the National Kidney Foundation website.)

Patients may exhibit few to no symptoms during the earliest stages of chronic kidney failure. This only makes it that much harder for specialists to diagnose before it has become more advanced, even with more modern imaging capabilities. In fact, the issue may not reveal itself until after kidney function has dropped off significantly. Treatment for CKD is designed to preserve as much function as possible by slowing down the diseases progression. In some cases, the patient may develop end-stage kidney failure, which can be fatal.

What Causes Kidney Failure?

The effective treatment of someone with chronic kidney disease will depend on the ability to address the underlying issues. Some of the issues that can cause renal impairment are directly treatable, but there are some that aren’t. In order to narrow down our focus, we are going to be looking at what might cause acute kidney injury and what can cause chronic problems.

There are three common causes of acute kidney injuries:

  • Significant and sudden loss of blood flow to the kidneys. Injuries or severe infections (sepsis) can lead to significant blood loss which means less getting to the kidneys. Serious dehydration may also play a role.
  • Suffering internal damage as a result of some medicines, poisons, or infections. People who are living with life-long health complications should know they run a greater risk of incurring kidney issues from taking a new medication. These can include pain medications and antibiotics.
  • Kidney stones or some other blockage that can prevent the effective evacuation of urine. Such things like tumors, injuries and enlarged prostates could also cause this type of blockage.

Chronic kidney disease (also referred to as chronic kidney failure or CKD) often takes months or even years for symptoms to develop. Here are some of the more common underlying causes:

  • Poorly managed diabetes
  • Poorly managed high blood pressure (hypertension)
  • Development of chronic glomerulonephritis

The following complications are less common but can still cause renal impairment over time:

  • Reflux nephropathy
  • Prostate disease
  • Kidney stones
  • Polycystic kidney disease

Clinical studies have shown that patients meeting the following criteria tend to be at greater risk for developing some form of renal impairment:

  • Older adults (above the age of 55)
  • Been living with some other underlying condition such as diabetes, heart disease, hypertension, liver disease, or obesity
  • Getting heart surgery or a bone marrow transplant

ESRD Compared to CKD

Reaching end-stage renal disease means that the patient will no longer be able to survive without the help of routine dialysis or a kidney transplant. CKD will also damage your kidneys, but you won’t require such drastic steps to stay alive. You could consider ESRD as complete kidney failure.

Anyone who is interested in one of our renal impairment clinical trials should know that the required level of participation will change from trial to trial. Participating in a clinical trial here in DeLand, FL may only require agreeing to let our researchers have a copy of your test results– most will require a little more involvement than that.

Qualified participants will be compensated for time and travel, and any study related care. The following are all provided free of charge:

  • Physical examinations
  • Laboratory services
  • Study related medication

Renal Impairment Clinical Trials in DeLand, Florida

Avail Clinical Research is currently conducting a wide array of clinical studies targeted towards certain conditions. If you are 18 years of age or older, you may be eligible to participate in one of our Florida kidney failure clinical trials and contribute to the development and approval of a new drug or treatment. As a participant, there is no cost to you at any point during the study and health insurance is not required. Browse our clinical trials being conducted now to find the study best suited for you.

A Video on the Causes of Renal Failure

Resources on Chronic Kidney Disease & Renal Impairment

If you live near Central Florida, click here to learn more about participating in a renal impairment clinical trial. Also, our sister site Achieve Clinical Research conducts renal impairment clinical trials in Birmingham, Alabama.


Clinical Trial Indications